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Inhibition of focal adhesion kinase (FAK) rescued SERT purpose in synapses of KI mice, demonstrating that constitutive Energetic FAK signaling downstream on the Pro32Pro33 integrin αvβ3 suppresses SERT activity. Our scientific studies discover a complex regulation of 5-HT homeostasis and behaviors by integrin αvβthree, revealing a very importan

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The arena was brightly lit through the take a look at. Inside the novelty tests, naive animals had been positioned in the middle of the arena and permitted to investigate the chamber for ten min. The habituation testing was carried out over the day once the novelty screening, exactly where mice were reintroduced into the arena and permitted to disc

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